Figure 5.

Anion permeability of the cisplatin-activated chloride channel. Anion selectivity of the cisplatin-activated chloride channel was determined by replacing the 70 mM NaCl of the isotonic solution with equimolar Na (X), where X represents the substituted anion I⁻, Br⁻ or gluconate. The anion permeability, relative to that of Cl⁻, was calculated from the shift in reverse potential. The order of anion permeability was Cl⁻=I⁻> Br⁻>gluconate acid ion. The data represent the mean ± standard error of six experiments. ^*P<0.05 and ^**P<0.01, vs. Cl⁻.