Figure 2. Dopamine transporter knockout alters periodicity of ultradian locomotor rhythms in circadian incompetent mice under constant darkness.
(A) Representative, double-plotted actograms demonstrating marked lengthening of ultradian locomotor periods in SCNx-Slc6a3−/− mice as compared to SCNx-Slc6a3+/+ littermates. Tau(τ) indicates individual period. (B) Period length averages of ultradian activity (N = 7; F1,6 = 253.8, ***p < 0.0001, ANOVA) from Lomb-Scargle periodogram analysis of 7-day time-spans. (C) Representative, double-plotted actograms demonstrating markedly increased ultradian period lengths in Bmal1−/−, Slc6a3−/− mice as compared to Bmal1−/−, Slc6a3+/+ mice. (D) Period length averages of ultradian activity (N = 4; F1,3 = 194.2, ***p < 0.001, ANOVA) from Lomb-Scargle periodogram analysis of 7-day time- spans.