Figure 1.
Influence of sex on plasma pegaptanib levels over time.
Notes: (A) Patients treated with a single dose of 0.3 mg pegaptanib/eye had a rate of 47% below the lower limit of quantification (BLQ), and therefore, these data were not pooled by dose-normalization. (B) Patients in the 1.0 mg and 3.0 mg pegaptanib/eye cohorts had similar rates of BLQ readings (17% and 8%, respectively), and were pooled by dose-normalizing, allowing for greater statistical power. This provided evidence that males treated with either 1.0 mg or 3.0 mg pegaptanib had a higher maximum concentration (Cmax), but lower plasma concentrations during the terminal phase and thus, a faster terminal elimination rate than females.
Abbreviations: F, females; h, hour; Geo, geometric; M, males; PRED, prediction.