Figure 2.

Influence of the covariate creatinine clearance (CRCL) on plasma pegaptanib levels over time.

Notes: Data from patients were stratified based on CRCL values >70.5 mL/min or ≤70.5 mL/min, which was the median CRCL value for this study. (A) Patients treated with a single dose of 0.3 mg pegaptanib/eye had a rate of 47% below the lower limit of quantification (BLQ), and therefore, these data were not pooled by dose normalization. (B) Patients in the 1.0 mg and 3.0 mg pegaptanib/eye cohorts had similar rates of BLQ readings (17% and 8%, respectively), and were pooled by dose normalizing, allowing for greater statistical power. This provided evidence that patients with a CRCL ≤70.5 mL/min had higher maximum concentration values and higher plasma concentrations than those with CRCL >70.5 mL/min.

Abbreviations: h, hour; Geo, geometric; min, minute; PRED, prediction.