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Nominal schedule of plasma sampling for pharmacokinetic analysis
| Schedule for the first dose | Schedule for the third dose |
|---|---|
| Predose | Predose (week 12 prior to dosing) |
| 4±2 hours (day 0) | 4±2 hours postdose (week 12) |
| 24±4 hours (day 0) | 24±4 hours (week 12) |
| Week 1±3 days | Week 13±3 days |
| Week 3±3 days | Week 15±3 days |
| Week 6 (just prior to second dose) | Week 18 (just prior to fourth dose) |
