Figure 4.

Acute administration of AQW051 improves learning/memory in the social recognition task in mice. Bars represent the mean time (s) within the 3 min trial during which the adult female mice scrutinized the young partner (n = 10 pairs of mice per treatment group). Black bars, time scrutinizing a young mouse during the baseline trial; grey bars, time scrutinizing the familiar (previously encountered) or an unfamiliar partner during the re-test trial performed 24 h after the baseline trial. AQW051 (0.03 or 0.3 mg·kg⁻¹ p.o.) and oxiracetam (100 mg·kg⁻¹ s.c.) was administered 1 h before the baseline trial. Comparisons with baseline trial within each treatment group were made using the Mann–Whitney U-test. Significant values of *P < 0.001 and **P < 0.01 are shown.