Figure 6.

AQW051 enhances spatial navigation in the water maze test. Mice were given four visual cue test trials on day −1 (visual) and counterbalanced to AQW051 and vehicle groups using their trial 4 swimming distance. Compound was administered at day 0 and days 1–3, 1 h before testing. On days 1 and 2, four acquisition trials were run, and to avoid over-training, only two trials were run on day 3. For acquisition training on days 1–3, there was an anova Drug × Day interaction. Single day re-analysis identified anova Drug × Trial interaction, and using post hoc Dunnett's test, decreased swimming distance (i.e. enhanced spatial navigation) on trial 1 specifically in AQW051-treated compared with vehicle-treated rats, on days 1 and 2. Values are expressed as mean (±SEM).