Figure 7.

Comparative effects of AQW051 and chlordiazepoxide administered to rats at different time points before the social exploration test. Bars represent the mean time (s ± SEM per 5 min trial) spent by the ‘intruder’ juvenile male rat actively exploring the ‘resident’ adult male rat. Intruder rats received either vehicle or single doses of AQW051 (1 mg·kg⁻¹ p.o.) at 1, 3, 6 or 16 h before the test. Three additional groups of intruder rats received single doses of the positive control, chlordiazepoxide (1 mg·kg⁻¹ p.o.), at 1, 6 or 16 h before the test. For each group, 10 rats were used. Data were analysed by anova followed by a post hoc Dunnett's test. *P < 0.05 versus vehicle-treated rats.