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Effects of AQW051 at human α7-nAChR, α3β4, α4β2, α1β1γδ and murine 5-HT3 receptors using a fluorescence readout (Feuerbach et al., 2005)
| Receptor | n | pEC50 ± SEM | Emax ± SEM | pIC50 ± SEM | Selectivity |
|---|---|---|---|---|---|
| α7 | 18 | 7.41 ± 0.09 | 73 ± 4.1% | ||
| α1β1γδ | 6 | 4.97 ± 0.05 | 274 | ||
| α4β2 | 6 | 5.40 ± 0.07 | 101 | ||
| α3β4 | 5 | 5.28 ± 0.08 | 144 | ||
| 5-HT3 | 6 | 4.72 ± 0.09 | 488 |
