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Effect of acute AM251 administration (0.5 mg·kg−1, i.p.) on PCP-induced (A) hyperlocomotion and stereotyped behaviour, (B) cognitive deficits in the classic and spatial NOR test, (C) social withdrawal and aggressive behaviours in the social interaction test and (D) immobility in the FST. Data are expressed as mean ± SEM (n = 6 per group). *P < 0.05, **P < 0.01, ***P < 0.001 versus vehicle-saline; °P < 0.05, °°P < 0.01, °°°P < 0.001 versus vehicle-PCP (Bonferroni's post hoc test).
