Table 1.
Effect of 100 nM Δ9-THCV on the mean EC50 and Emax values of 8-OH-DPAT for its stimulation of [35S]-GTPγS binding to membranes obtained from Sprague–Dawley rat brainstem or human 5-HT1A CHO cells
| Pretreatment | Tissue | EC50, nM (95% CI) | Emax, % (95% CI) | n |
|---|---|---|---|---|
| Vehicle (DMSO) | Rat brainstem | 1301 (234, 7236) | 45.0 (30.0, 60.0) | 11 |
| 100 nM THCV | Rat brainstem | 5.4* (0.4, 67.4) | 34.7 (27.8, 41.5) | 11 |
| Vehicle (DMSO) | Human 5-HT1A CHO cells | 18.4 (8.8, 38.5) | 108.5 (99.7, 117.4) | 8 |
| 100 nM THCV | Human 5-HT1A CHO cells | 28.3 (14.9, 53.7) | 133.8* (124.5, 143.1) | 8 |
The 95% confidence intervals (CI) are shown in parentheses. *The 95% confidence intervals of this mean value do not overlap with those of the mean value in the previous row, indicating it to be significantly lower than the mean value obtained from experiments with vehicle-treated membranes (P < 0.05). See also Figure 2A and D.