Table 2.
Mean IC50 and maximal percentage displacement values for the displacement of 8-[3H]-OH-DPAT from specific binding sites in membranes obtained from Sprague–Dawley rat brainstem or human 5-HT1A CHO cells
| Compound | Tissue | IC50, nM (95% CI) | Maximal displacement, % (95% CI) | n |
|---|---|---|---|---|
| 8-OH-DPAT | Rat brainstem | 0.8 (0.4, 1.4) | 107.6 (95.4, 119.8) | 4–9 |
| Δ9-THCV | Rat brainstem | 0.002 (0.0002, 0.002) | 33.5* (27.0, 40.0) | 4–9 |
| 8-OH-DPAT | Human 5-HT1A CHO cells | 0.9 (0.5, 1.7) | 96.5 (90.1, 102.9) | 6 |
| Δ9-THCV | Human 5-HT1A CHO cells | 2060 (194.6, 21810) | −45.4*† (−73.5, −17.4) | 10 |
*
The 95% confidence intervals (CI) are shown in parentheses. *The 95% CIs of this mean value do not overlap with those of the mean value in the previous row, indicating it to be significantly lower than the mean value obtained from experiments with vehicle-treated membranes (P < 0.05). See also Figure 2C and F.
†
The 95% CIs of this mean maximal displacement value indicate it to be significantly less than zero (P < 0.05). See also Figure 2F.