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Heart work [heart rate × left ventricular developed pressure (LVDP)] (A) was measured in isolated hearts after 14 days of treatment by meldonium (100 mg·kg−1) or Methyl-GBB (1, 5 and 20 mg·kg−1). Heart function in vivo (B) was measured by echocardiography after 14 days of treatment by meldonium (100 mg·kg−1) or Methyl-GBB (1, 5 and 20 mg·kg−1). Data shown are the means ± SEM of 5–10 animals.
