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. 2015 Jan 8;172(5):1379–1394. doi: 10.1111/bph.13016

Figure 1.

Figure 1

Dose and time-dependent effects of tamoxifen, raloxifene and toremifene on DiI-LDL uptake by lymphocytes from normolipidaemic men. (A) Lymphocytes from five male donors were treated with DiI-LDL and vehicle (control), tamoxifen (TAM), raloxifene (RAL) or toremifene (TOR) for 24 h as indicated. Data (mean ± SEM) are expressed as % of the control of the same cell preparation. (B) Lymphocytes from five male donors were treated with DiI-LDL and vehicle (control) or 5 μM SERMs for the indicated times. Data (mean ± SEM) are expressed as % of the control at 8 h of the same cell preparation. The trends were compared by two-way RM anova and post hoc by Student–Newman–Keuls test. *P < 0.05, **P < 0.01, ***P < 0.001.