Figure 3.

Effect of vitamin E on the SERM-mediated stimulation of the expression of active LDL receptor. Lymphocytes from four male donors were treated with 60 μg·mL⁻¹ LDL plus vehicle (control) or 5 μM tamoxifen (TAM), raloxifene (RAL) or toremifene (TOR) and combined or not with different concentrations of vitamin E for 22 h as indicated, then the media were replaced with fresh medium containing 30 μg·mL⁻¹ DiI-LDL and DiI-LDL uptake was measured after an additional 2 h incubation. Data (mean ± SEM) are expressed as % of the condition with LDL alone of the same cell preparation. The trends were compared by two-way RM anova and post hoc by the Student–Newman–Keuls test. ^**P < 0.01, ^***P < 0.001.