Figure 5.

Effects of tamoxifen, raloxifene and toremifene on gene expression. Lymphocytes from four male donors were treated with 10% LPDS alone or supplemented with 60 μg·mL⁻¹ LDL plus vehicle (control) or 5 μM tamoxifen (TAM), raloxifene (RAL) or toremifene (TOR) for 8 h. The mRNA levels of the indicated genes are expressed as the relative amount of mRNA compared with that under the LPDS condition of the same cell preparation, which was set to 1. Statistical analysis was performed by one-way RM anova and post hoc by Student–Newman–Keuls test. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus control; ##P < 0.01, ###P < 0.001 versus TAM; §§P < 0.01, §§§P < 0.001 versus TOR.