Clinically used selective oestrogen receptor modulators increase LDL receptor activity in primary human lymphocytes

. 2015 Jan 8;172(5):1379–1394. doi: 10.1111/bph.13016

TARGETS
Nuclear hormone receptors^a	Enzymes^c
Liver X receptor (LXR)	Acyl-CoA:cholesterol acyltransferase (ACAT)
Oestrogen receptors	Cytochrome P-450 2D6 (CYP2D6)
Oestrogen receptor-α (ERα)	Fatty acid synthase
Transporters^b	HMG-CoA reductase
ABCA1