Table 1.

Recent prospective, randomized, controlled, double-blind Phase III studies for the symptomatic treatment of seasonal allergic rhinitis caused by ragweed pollen

Reference	Randomized participants	Geographic region*	Multicenter	Agent	Study design	Primary endpoint	Validated outcome measure?	Significant difference of primary endpoint?
Kaiser et al51	299	Northern America	Yes	Topical fluticasone furoate	15 days (during local allergy season), two arms: 1 10 mg versus placebo	Symptom score	No	Yes
Patel et al44	320	Northern America	No	Topical olopatadine	1 day (allergen challenge chamber), four arms: once at 0.2%; 0.4%; or 0.6% versus placebo	Symptom score	Environmental exposure chamber was validated against natural exposure45,46	Yes (0.6%)
Patel and Patel47	403	Northern America	No	Oral levocetirizine versus montelukast versus placebo	2 days (allergen challenge chamber), three arms: levocetirizine 5 mg once daily versus montelukast 10 mg once daily versus placebo	Symptom score	No	Yes (levocetirizine)
Day et al50	379	Northern America	Yes	Oral loratadine and montelukast versus phenylephrine versus placebo	2 days (allergen challenge chamber), three arms: loratadine 10 mg and montelukast 10 mg once daily versus phenylephrine 10 mg once daily versus placebo	Peak nasal flow	No	Yes (loratadine and montelukast)
Moinuddin et al48	72	Northern America	No	Oral fexofenadine and pseudoephedrine versus loratadine and montelukast	2 weeks (during local allergy season), two arms: fexofenadine 60 mg and pseudoephedrine 120 mg twice daily versus loratadine, 10 mg and montelukast, 10 mg once daily	Not specifically designated	Rhinoconjunctivitis Quality of Life Questionnaire45	Not applicable

Note:

^*Geographical subregion as defined by the United Nations Organization.