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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Med Res Rev. 2014 May 14;35(1):1–62. doi: 10.1002/med.21319

Table XIX.

Biological Data for 5-FU–DEPPT Conjugates 537–548

graphic file with name nihms-662637-t0046.jpg
Cytotoxic activity (IC50, μM)a
Compound K562b AGSc HL-60b A-549c log P
ETO >100 50.8 2.75 7.38 0.69
5-FU >100 >100 65.3 50.5 –
537 19.5 40.4 22.3 2.59 −0.07
538 13.5 62.5 5.80 1.92 0.34
539 30.8 140.8 23.2 6.95 −0.12
540 9.5 59.2 0.13 0.01 0.33
541 5.1 56.2 0.24 0.18 0.59
542 8.8 24.8 0.99 0.29 0.23
543 5.8 23.6 0.31 0.48 0.65
544 28.6 114.7 26.6 21.7 0.07
545 5.3 34.5 0.73 <0.01 0.35
546 9.2 23.7 0.42 0.30 0.43
547 6.0 23.5 0.31 0.53 0.51
548 13.2 38.8 0.04 <0.01 0.29
a

Average of triplicate experiments.

b

The microculture [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method, 48 hr drug exposure.

c

the sulforhodamine B (SRB) colorimetric assay method, 72 hr drug exposure.