Table XXVII.
Cytotoxicity Data for Triazole Analogs 674–682
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---|---|---|---|---|---|---|
IC50 (μM) |
||||||
Compound | DU-145 | PC-3 | A549 | HCT-15 | HOP-62 | SF-295 |
ETO | 2.97 | 100 | 7.63 | 1 | 4.8 | 5.69 |
674 | 25.8 | 127 | 125 | 15 | NTa | 26.8 |
675 | 42 | 221 | 556 | NT | 142 | 35.1 |
676 | 237 | 316 | 59.9 | 16 | 178 | 14.5 |
677 | 18.6 | 94.9 | 51.8 | 237 | 121 | 53.4 |
678 | 26.5 | 268 | 114 | NT | NT | 88 |
679 | 3.11 | 34.6 | 3 | 0.93 | 8.55 | 2.01 |
680 | 4.95 | 24.3 | 6.88 | 1 | 5.27 | 16.1 |
681 | 2.73 | 8.62 | 7.33 | 3.57 | 5.96 | 2.51 |
682 | 5.04 | 20.8 | 7.04 | 2.14 | 16.2 | 8.29 |
NT, not tested.