. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Med Res Rev. 2014 May 14;35(1):1–62. doi: 10.1002/med.21319

Table III.

Cytotoxicity Data for Pinacol, Alkylidene, and Alkyl Analogs 97–122


	GI₅₀ ± SD (nM)^a
Compound	A-549	HT-29	SK-BR3
EPPT	60	60	NT
97	6220 ± 562	5230 ± 443	5870 ± 126
98	6020 ± 526	6560 ± 456	6140 ± 786
99	279 ± 12	404 ± 75	288 ± 8
100	2030 ± 15	2510 ± 413	2430 ± 9
101	1480 ± 564	659 ± 43	511 ± 65
102	577 ± 61	598 ± 83	457 ± 24
103	254 ± 6	204 ± 2	181 ± 7
104	1150 ± 27	1730 ± 87	1030 ± 70
105	2620 ± 65	4750 ± 126	4990 ± 345
106	139 ± 5	159 ± 16	148 ± 15
107	874 ± 68	528 ± 20	524 ± 36
108	376 ± 25	281 ± 32	313 ± 57
109	191 ± 18	198 ± 18	219 ± 40
110	1690 ± 356	2720 ± 315	2420 ± 154
111	444 ± 12	451 ± 8	439 ± 29
112	547 ± 71	859 ± 13	610 ± 24
113	90.8 ± 1.3	97.5 ± 4.6	64.9 ± 2.8
114	5680 ± 6	6420 ± 85	6720 ± 41
115	6.39 ± 0.15	5.14 ± 0.50	7.39 ± 0.6
116	8920 ± 317	15440 ± 491	8010 ± 140
117	29.0 ± 1.1	26.8 ± 0.3	25.9 ± 0.4
118	3320 ± 213	2620 ± 53	1780 ± 187
119	6440 ± 477	8280 ± 386	3780 ± 82
120	79.5 ± 9.0	83.1 ± 1.4	84.1 ± 3.0
121	7700 ± 137	10200 ± 221	4530 ± 141
122	6210 ± 326	11400 ± 582	14300 ± 589

Cytotoxicity results are expressed as GI₅₀ values, the compound concentration producing a 50% cell growth inhibition and represent the mean ± SD of three independent experiments. Values under 100 nM are highlighted for easier comparison.