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. Author manuscript; available in PMC: 2016 Feb 12.
Published in final edited form as: J Med Chem. 2015 Jan 23;58(3):1307–1319. doi: 10.1021/jm5015742

Fig 1.

Fig 1

Binding of fluconazole and compound 18 (NO2-fluconazole) to T. cruzi CYP51. Both compounds produce typical type 2 spectral response in T. cruzi CYP51, indicating at least initial coordination of triazole N4 to the P450 heme iron. However, compound 18 is a weaker binder.