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. Author manuscript; available in PMC: 2016 Feb 12.
Published in final edited form as: J Med Chem. 2015 Jan 23;58(3):1307–1319. doi: 10.1021/jm5015742

Scheme 1. Preparation of compounds 2-21.

Scheme 1

i) Et3N, CH2Cl2, RT; ii) 3-Nitro-1,2,4-triazole/2-nitroimidazole, KOH, CH3CN, reflux 9h; iii) 3-Nitro-1,2,4-triazole/2-nitroimidazole, KOH, CH3CN, α-bromoketone, reflux 5-6 h; iv) KOH in H2O:2-propanol, reflux 1h; v) NaH (60%), propanol-1, reflux 6 h.