. Author manuscript; available in PMC: 2016 Feb 12.

Published in final edited form as: J Med Chem. 2015 Jan 23;58(3):1307–1319. doi: 10.1021/jm5015742

Table 3. Binding of compounds to recombinant T. cruzi CYP51.

Compound	K_d (μM)	I/E₂ (5 min)	I/E₂ (1 h)
2	ND	4	36
18	0.606 ± 0.023	5	32
19	0.023 ± 0.012	<1	3
23	65.2 ± 5.3	ND	ND
Fluconazole	0.230 ± 0.029	<1	16
Bnz*	ND	43.2	45

K_d: Dissociation constant. I/E₂: Molar ratio of inhibitor/enzyme which causes a 2-fold decrease in enzyme activity in 5 min and 1 hour reactions. ND: Not determined.

Values for Bnz were taken from Ref. [30].