. Author manuscript; available in PMC: 2016 Feb 12.

Published in final edited form as: J Med Chem. 2015 Jan 23;58(3):1307–1319. doi: 10.1021/jm5015742

Table 4.

In vitro ADME data for compounds 2 and 19.

Compound	mean A->B P_app (×10^-6cm s^-1)	Test species	Mean remaining parent, with NADPH (%)	Mean remaining parent, free of NADPH (%)
2	18.7	Human	96.8	84.8
2	18.7	Mouse	79.4	110
19	16.5	Human	90.7	106
19	16.5	Mouse	77.6	102
Verapamile		Human	8.4	89.4
Verapamile		Mouse	6.0	96.5
Warfarin	25.3	Human	102	96.7
Warfarin	25.3	Mouse	104	101
Ranitidine	0.24

Papp: Caco 2 apparent permeability. Permeability ranking: Low: <0.5; Moderate: 0.5 - 5; High: > 5. For permeability measurements 10 μM concentration was used and 2 h assay time. For metabolic stability, 1 μM concentration and 0 and 60 min incubation time was used. Test species represent either human or mouse microsomes.