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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: J Neurophysiol. 2002 Oct;88(4):1851–1858. doi: 10.1152/jn.2002.88.4.1851

FIG. 6.

FIG. 6

Cellular effects of Nic agonist RJR-2403 (RJR) and Antags MLA and DH-β-E. RJR induced a tonic inward current (A) and decreased the amplitude of inspiratory drive currents (B) in preBötC inspiratory neurons voltage-clamped at −60 mV. The effects of MLA (n = 5) were not significant, whereas DH-β-E (n = 6) reversed the RJR-induced responses. Effects on amplitude of phasic inspiratory drive current presented were normalized by the values prior to application of RJR, whereas the nonnormalized data were used for statistical tests. One-way repeated-measures ANOVA for each group and post hoc analysis based on Tukey were used. +, statistically significant difference between RJR and basline (BasL) conditions. *, statistically significant difference between Antag and RJR conditions. Summary of the effects of RJR, MLA, and DH-β-E on frequency (C) and amplitude (D) of spontaneous EPSCs (sEPSCs). sEPSCs were recorded for 1–2 min and 100–600 events were collected in each condition for each neurons. Each symbol indicates 1 neuron. Refer to results for statistical analyses for C and D.