Figure 1.
Virus schema and Measles virus CD46 receptor expression. (A) Genomic organization of MV-Edm derivatives, MV-GFP and MV-NIS. N, nucleoprotein; P, phosphoprotein; M, matrix protein; F, fusion protein; H, hemagglutinin; L, large protein; GFP, green fluorescent protein; NIS, sodium iodide symporter. (B) osteosarcoma cell lines were tested for the MV receptors, CD46 and Nectin-4, by flow cytometry. Solid line histograms represent isotype control staining, while CD46 staining is represented by shaded histograms. CD46 expression was detectable in all cell lines tested.