TABLE 1.
Study time point | Animal group | Tumor 18F-FDG uptake SUVmax
|
Tumor-to-liver ratio
|
Tumor maximal axial diameter (cm)
|
Normal liver SUVmax | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | P value 1 | P value 2 | Mean | SD | P value 1 | P value 2 | Mean | SD | P value 1 | P value 2 | |||
Baseline | TG | 6.10 | 2.42 | 2.49 | 0.81 | 1.91 | 0.71 | 2.49 | ||||||
SG | 6.06 | 2.75 | 0.51 | 2.70 | 1.26 | 0.67 | 2.27 | 0.85 | 0.88 | 2.34 | ||||
| ||||||||||||||
After treatment
| ||||||||||||||
2 h | TG | 3.32 | 3.17 | 0.009 | 1.4 | 0.7 | 0.005 | 2.45 | 0.49 | 0.98 | 2.19 | |||
SG | 4.61 | 1.47 | 0.12 | 0.87 | 1.89 | 0.52 | 0.09 | 0.91 | 2.56 | 0.83 | 0.38 | 0.26 | 2.57 | |
| ||||||||||||||
24 h | TG | 3.06 | 0.87 | 0.0005 | 1.17 | 0.33 | 0.002 | 2.58 | 0.67 | 0.96 | 3.33 | |||
SG | 5.30 | 2.00 | 0.09 | 0.67 | 1.72 | 0.21 | 0.01 | 0.95 | 2.66 | 0.56 | 0.42 | 0.20 | 3.10 | |
| ||||||||||||||
1 wk | TG | 4.18 | 1.36 | 0.01 | 1.56 | 0.71 | 0.02 | 2.76 | 0.72 | 0.01 | 2.97 | |||
SG | 9.00 | 3.17 | 0.006 | 0.05 | 3.47 | 1.1 | 0.003 | 0.13 | 3.05 | 0.84 | 0.27 | 0.05 | 2.93 |
Intergroup comparisons (P value 1) and intragroup comparisons (P value 2, comparison to baseline values) were made using mean values for each variable, and P < 0.05 indicates statistically significant differences between groups. P values refer to unpaired t tests with unequal variance. Reference SUVmax of normal hepatic parenchyma are also included.