Table 2.

Association between higher genetic risk (≥12 risk alleles) and prostate cancer adjusted for age and education, stratified by environmental factors, PLCO

	OR (95% CI) of higher genetic risk (≥12 risk alleles)
	Total	Nonadvanced stage	Advanced stage	Aggressive (advanced stage or Gleason sum ≥8)	Low grade (Gleason sum ≤6)	Intermediate grade (Gleason sum 7)	High grade (Gleason sum ≥8)
Overall	1.98 (1.67–2.34)	1.91 (1.54–2.36)	2.04 (1.67–2.49)	1.73 (1.33–2.25)	1.93 (1.56–2.37)	2.33 (1.86–2.93)	1.45 (0.97–2.15)
BMI at age 20
Normal	2.11 (1.73–2.57)	2.09 (1.62–2.68)	2.13 (1.69–2.70)	1.93 (1.42–2.63)	2.10 (1.64–2.68)	2.39 (1.83–3.12)	1.59 (1.00–2.53)
Overweight	1.78 (1.23–2.58)	1.59 (0.98–2.57)	1.93 (1.24–3.00)	1.58 (0.89–2.79)	1.62 (1.02–2.58)	2.30 (1.37–3.86)	1.41 (0.57–3.50)
Obese	0.69 (0.19–2.57)	0.59 (0.10–3.56)	0.90 (0.18–4.55)	0.52 (0.06–4.35)	0.45 (0.08–2.48)	1.29 (0.21–7.80)	0.19 (0.00–9.88)
Aspirin
Nonuser	2.25 (1.80–2.83)	2.25 (1.68–3.00)	2.26 (1.73–2.95)	1.89 (1.34–2.67)	2.47 (1.86–3.28)	2.49 (1.85–3.36)	1.44 (0.84–2.49)
User	1.67 (1.30–2.15)	1.54 (1.12–2.13)	1.79 (1.32–2.42)	1.54 (1.03–2.30)	1.41 (1.03–1.92)	2.14 (1.51–3.04)	1.47 (0.82–2.64)
Ibuprofen
Nonuser	2.02 (1.68–2.42)	1.99 (1.58–2.51)	2.04 (1.64–2.53)	1.86 (1.40–2.46)	2.04 (1.63–2.56)	2.25 (1.76–2.87)	1.57 (1.03–2.39)
User	1.75 (1.13–2.71)	1.43 (0.83–2.49)	2.05 (1.21–3.49)	1.14 (0.57–2.26)	1.34 (0.78–2.30)	2.88 (1.56–5.33)	0.75 (0.20–2.80)
Fruit intake
Tertile 1	2.04 (1.50–2.78)	2.17 (1.45–3.26)	1.94 (1.35–2.80)	1.52 (0.96–2.42)	2.16 (1.46–3.20)	2.39 (1.58–3.63)	1.20 (0.56–2.57)
Tertile 2	2.07 (1.54–2.80)	1.86 (1.28–2.72)	2.27 (1.59–3.23)	2.17 (1.35–3.50)	1.89 (1.31–2.72)	2.53 (1.69–3.80)	1.82 (0.92–3.60)
Tertile 3	1.76 (1.30–2.38)	1.73 (1.19–2.50)	1.78 (1.24–2.56)	1.54 (0.97–2.45)	1.80 (1.25–2.59)	2.06 (1.35–3.13)	1.19 (0.58–2.43)
Vegetable intake
Tertile 1	1.97 (1.46–2.66)	2.23 (1.53–3.25)	1.76 (1.23–2.51)	1.34 (0.86–2.09)	2.18 (1.52–3.13)	2.39 (1.58–3.63)	0.78 (0.38–1.59)
Tertile 2	1.92 (1.43–2.60)	1.67 (1.14–2.44)	2.16 (1.51–3.09)	1.82 (1.15–2.87)	1.76 (1.22–2.55)	2.47 (1.63–3.73)	1.64 (0.83–3.24)
Tertile 3	1.94 (1.43–2.64)	1.81 (1.23–2.67)	2.09 (1.44–3.02)	2.30 (1.37–3.84)	1.84 (1.25–2.70)	2.07 (1.38–3.11)	2.51 (1.11–5.67)
Vitamin D intake
Tertile 1	1.72 (1.26–2.34)	1.62 (1.08–2.41)	1.78 (1.24–2.55)	1.46 (0.90–2.37)	1.60 (1.08–2.36)	2.20 (1.46–3.31)	0.98 (0.45–2.15)
Tertile 2	1.91 (1.42–2.56)	1.80 (1.25–2.60)	2.02 (1.43–2.87)	1.66 (1.08–2.57)	1.92 (1.34–2.75)	2.02 (1.36–3.00)	1.99 (1.05–3.78)
Tertile 3	2.26 (1.67–3.07)	2.34 (1.60–3.42)	2.20 (1.52–3.20)	2.11 (1.29–3.43)	2.27 (1.58–3.26)	2.81 (1.81–4.36)	1.18 (0.55–2.56)
Folate intake
Tertile 1	1.99 (1.47–2.70)	1.95 (1.31–2.90)	2.02 (1.41–2.88)	1.72 (1.08–2.75)	1.89 (1.29–2.77)	2.30 (1.54–3.43)	1.36 (0.62–3.00)
Tertile 2	1.61 (1.19–2.16)	1.54 (1.06–2.23)	1.69 (1.18–2.40)	1.36 (0.88–2.12)	1.56 (1.08–2.24)	1.91 (1.26–2.87)	1.42 (0.74–2.70)
Tertile 3	2.38 (1.75–3.23)	2.39 (1.63–3.48)	2.40 (1.65–3.50)	2.37 (1.44–3.91)	2.53 (1.74–3.67)	2.88 (1.87–4.44)	1.47 (0.70–3.06)
Lycopene intake
Tertile 1	2.14 (1.58–2.92)	2.36 (1.57–3.53)	1.99 (1.40–2.84)	1.60 (1.01–2.55)	2.39 (1.62–3.52)	2.41 (1.61–3.62)	0.99 (0.47–2.05)
Tertile 2	1.95 (1.45–2.63)	1.94 (1.34–2.80)	1.97 (1.37–2.81)	1.53 (0.97–2.40)	1.86 (1.30–2.66)	2.38 (1.57–3.61)	1.78 (0.85–3.70)
Tertile 3	1.74 (1.29–2.36)	1.50 (1.03–2.19)	2.00 (1.38–2.88)	2.04 (1.25–3.34)	1.60 (1.11–2.32)	2.11 (1.39–3.20)	1.60 (0.79–3.26)
Selenium supplement
Nonuser	2.01 (1.68–2.40)	1.94 (1.55–2.43)	2.06 (1.67–2.55)	1.79 (1.37–2.36)	1.97 (1.59–2.45)	2.35 (1.85–3.00)	1.54 (1.01–2.36)
User	0.86 (0.33–2.25)	0.94 (0.29–3.08)	0.84 (0.24–2.88)	0.54 (0.08–3.53)	0.84 (0.25–2.82)	1.17 (0.30–4.64)	0.36 (0.03–4.05)

NOTE: Results are shown when P_interaction ≤ 0.15 (Supplementary Table S2). Results with P_interaction < 0.05 are shown in bold font.