Table 2.
OR (95% CI) of higher genetic risk (≥12 risk alleles)
|
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---|---|---|---|---|---|---|---|
Total | Nonadvanced stage | Advanced stage | Aggressive (advanced stage or Gleason sum ≥8) | Low grade (Gleason sum ≤6) | Intermediate grade (Gleason sum 7) | High grade (Gleason sum ≥8) | |
Overall | 1.98 (1.67–2.34) | 1.91 (1.54–2.36) | 2.04 (1.67–2.49) | 1.73 (1.33–2.25) | 1.93 (1.56–2.37) | 2.33 (1.86–2.93) | 1.45 (0.97–2.15) |
BMI at age 20 | |||||||
Normal | 2.11 (1.73–2.57) | 2.09 (1.62–2.68) | 2.13 (1.69–2.70) | 1.93 (1.42–2.63) | 2.10 (1.64–2.68) | 2.39 (1.83–3.12) | 1.59 (1.00–2.53) |
Overweight | 1.78 (1.23–2.58) | 1.59 (0.98–2.57) | 1.93 (1.24–3.00) | 1.58 (0.89–2.79) | 1.62 (1.02–2.58) | 2.30 (1.37–3.86) | 1.41 (0.57–3.50) |
Obese | 0.69 (0.19–2.57) | 0.59 (0.10–3.56) | 0.90 (0.18–4.55) | 0.52 (0.06–4.35) | 0.45 (0.08–2.48) | 1.29 (0.21–7.80) | 0.19 (0.00–9.88) |
Aspirin | |||||||
Nonuser | 2.25 (1.80–2.83) | 2.25 (1.68–3.00) | 2.26 (1.73–2.95) | 1.89 (1.34–2.67) | 2.47 (1.86–3.28) | 2.49 (1.85–3.36) | 1.44 (0.84–2.49) |
User | 1.67 (1.30–2.15) | 1.54 (1.12–2.13) | 1.79 (1.32–2.42) | 1.54 (1.03–2.30) | 1.41 (1.03–1.92) | 2.14 (1.51–3.04) | 1.47 (0.82–2.64) |
Ibuprofen | |||||||
Nonuser | 2.02 (1.68–2.42) | 1.99 (1.58–2.51) | 2.04 (1.64–2.53) | 1.86 (1.40–2.46) | 2.04 (1.63–2.56) | 2.25 (1.76–2.87) | 1.57 (1.03–2.39) |
User | 1.75 (1.13–2.71) | 1.43 (0.83–2.49) | 2.05 (1.21–3.49) | 1.14 (0.57–2.26) | 1.34 (0.78–2.30) | 2.88 (1.56–5.33) | 0.75 (0.20–2.80) |
Fruit intake | |||||||
Tertile 1 | 2.04 (1.50–2.78) | 2.17 (1.45–3.26) | 1.94 (1.35–2.80) | 1.52 (0.96–2.42) | 2.16 (1.46–3.20) | 2.39 (1.58–3.63) | 1.20 (0.56–2.57) |
Tertile 2 | 2.07 (1.54–2.80) | 1.86 (1.28–2.72) | 2.27 (1.59–3.23) | 2.17 (1.35–3.50) | 1.89 (1.31–2.72) | 2.53 (1.69–3.80) | 1.82 (0.92–3.60) |
Tertile 3 | 1.76 (1.30–2.38) | 1.73 (1.19–2.50) | 1.78 (1.24–2.56) | 1.54 (0.97–2.45) | 1.80 (1.25–2.59) | 2.06 (1.35–3.13) | 1.19 (0.58–2.43) |
Vegetable intake | |||||||
Tertile 1 | 1.97 (1.46–2.66) | 2.23 (1.53–3.25) | 1.76 (1.23–2.51) | 1.34 (0.86–2.09) | 2.18 (1.52–3.13) | 2.39 (1.58–3.63) | 0.78 (0.38–1.59) |
Tertile 2 | 1.92 (1.43–2.60) | 1.67 (1.14–2.44) | 2.16 (1.51–3.09) | 1.82 (1.15–2.87) | 1.76 (1.22–2.55) | 2.47 (1.63–3.73) | 1.64 (0.83–3.24) |
Tertile 3 | 1.94 (1.43–2.64) | 1.81 (1.23–2.67) | 2.09 (1.44–3.02) | 2.30 (1.37–3.84) | 1.84 (1.25–2.70) | 2.07 (1.38–3.11) | 2.51 (1.11–5.67) |
Vitamin D intake | |||||||
Tertile 1 | 1.72 (1.26–2.34) | 1.62 (1.08–2.41) | 1.78 (1.24–2.55) | 1.46 (0.90–2.37) | 1.60 (1.08–2.36) | 2.20 (1.46–3.31) | 0.98 (0.45–2.15) |
Tertile 2 | 1.91 (1.42–2.56) | 1.80 (1.25–2.60) | 2.02 (1.43–2.87) | 1.66 (1.08–2.57) | 1.92 (1.34–2.75) | 2.02 (1.36–3.00) | 1.99 (1.05–3.78) |
Tertile 3 | 2.26 (1.67–3.07) | 2.34 (1.60–3.42) | 2.20 (1.52–3.20) | 2.11 (1.29–3.43) | 2.27 (1.58–3.26) | 2.81 (1.81–4.36) | 1.18 (0.55–2.56) |
Folate intake | |||||||
Tertile 1 | 1.99 (1.47–2.70) | 1.95 (1.31–2.90) | 2.02 (1.41–2.88) | 1.72 (1.08–2.75) | 1.89 (1.29–2.77) | 2.30 (1.54–3.43) | 1.36 (0.62–3.00) |
Tertile 2 | 1.61 (1.19–2.16) | 1.54 (1.06–2.23) | 1.69 (1.18–2.40) | 1.36 (0.88–2.12) | 1.56 (1.08–2.24) | 1.91 (1.26–2.87) | 1.42 (0.74–2.70) |
Tertile 3 | 2.38 (1.75–3.23) | 2.39 (1.63–3.48) | 2.40 (1.65–3.50) | 2.37 (1.44–3.91) | 2.53 (1.74–3.67) | 2.88 (1.87–4.44) | 1.47 (0.70–3.06) |
Lycopene intake | |||||||
Tertile 1 | 2.14 (1.58–2.92) | 2.36 (1.57–3.53) | 1.99 (1.40–2.84) | 1.60 (1.01–2.55) | 2.39 (1.62–3.52) | 2.41 (1.61–3.62) | 0.99 (0.47–2.05) |
Tertile 2 | 1.95 (1.45–2.63) | 1.94 (1.34–2.80) | 1.97 (1.37–2.81) | 1.53 (0.97–2.40) | 1.86 (1.30–2.66) | 2.38 (1.57–3.61) | 1.78 (0.85–3.70) |
Tertile 3 | 1.74 (1.29–2.36) | 1.50 (1.03–2.19) | 2.00 (1.38–2.88) | 2.04 (1.25–3.34) | 1.60 (1.11–2.32) | 2.11 (1.39–3.20) | 1.60 (0.79–3.26) |
Selenium supplement | |||||||
Nonuser | 2.01 (1.68–2.40) | 1.94 (1.55–2.43) | 2.06 (1.67–2.55) | 1.79 (1.37–2.36) | 1.97 (1.59–2.45) | 2.35 (1.85–3.00) | 1.54 (1.01–2.36) |
User | 0.86 (0.33–2.25) | 0.94 (0.29–3.08) | 0.84 (0.24–2.88) | 0.54 (0.08–3.53) | 0.84 (0.25–2.82) | 1.17 (0.30–4.64) | 0.36 (0.03–4.05) |
NOTE: Results are shown when Pinteraction ≤ 0.15 (Supplementary Table S2). Results with Pinteraction < 0.05 are shown in bold font.