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. Author manuscript; available in PMC: 2015 Feb 23.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2014 Oct 23;24(1):213–220. doi: 10.1158/1055-9965.EPI-14-0786-T

Table 3.

Joint association of higher genetic risk score (≥12 risk alleles) and environmental factors with advanced- and nonadvanced-stage prostate cancer adjusted for age and education, PLCO

OR (95% CI)
<12 risk alleles ≥12 risk alleles
Advanced-stage prostate cancer
 Overall 1.00 (ref.) 2.04 (1.67–2.49)
Selenium supplement
 Nonuser 1.00 (ref.) 2.06 (1.67–2.55)
 User 1.43 (0.70–2.96) 0.99 (0.38–2.58)
Pinteraction = 0.031
Nonadvanced-stage prostate cancer
 Overall 1.00 (ref.) 1.91 (1.54–2.36)
Aspirin
 Nonuser 1.00 (ref.) 2.25 (1.69–3.00)
 User 1.10 (0.80–1.51) 1.70 (1.25–2.32)
Pinteraction = 0.009
Ibuprofen
 Nonuser 1.00 (ref.) 1.99 (1.58–2.52)
 User 1.10 (0.71–1.68) 1.62 (1.07–2.45)
Pinteraction = 0.023
Vegetable intake
 Tertile 1 1.00 (ref.) 2.24 (1.54–3.25)
 Tertile 2 1.05 (0.71–1.56) 1.76 (1.20–2.58)
 Tertile 3 0.95 (0.64–1.42) 1.71 (1.16–2.52)
Pinteraction = 0.010

NOTE: Results are shown when Pinteraction < 0.05 (Supplementary Table S2).