Table 2. IRR for CRC in relation to the studied polymorphisms.
| ncases (%) | nsub-cohort (%) | IRR a (95% CI) | IRR b (95% CI) | P-value c | ||
|---|---|---|---|---|---|---|
| TLR4 | rs4986790 | |||||
| AA | 839 (92) | 1577 (92) | 1.00 (ref.) | 1.00 (ref.) | - | |
| GA | 76 (8) | 141 (8) | 0.99 (0.79–1.25) | 1.00 (0.79–1.26) | 0.98 | |
| GG | 0 (0) | 1 (0) | - | - | - | |
| GA+GG | 76 (8) | 142 (8) | 0.99 (0.79–1.25) | 1.00 (0.79–1.26) | 0.97 | |
| rs5030728 | ||||||
| GG | 405 (44) | 826 (48) | 1.00 (ref.) | 1.00 (ref.) | - | |
| GA | 399 (44) | 731 (43) | 1.10 (0.96–1.26) | 1.11 (0.96–1.27) | 0.16 | |
| AA | 111 (12) | 162 (9) | 1.30 (1.06–1.61) | 1.30 (1.05–1.60) | 0.02 | |
| GA+AA | 510 (56) | 398 (23) | 1.14 (1.00–1.30) | 1.14 (1.00–1.30) | 0.05 | |
| AA vs. GG+GA | 111 (12) | 162 (9) | 1.24 (1.02–1.52) | 1.24 (1.01–1.51) | 0.04 | |
| NFKB1 | rs28362491 | |||||
| Ins/Ins | 320 (35) | 679 (60) | 1.00 (ref.) | 1.00 (ref.) | - | |
| Ins/Del | 449 (49) | 787 (46) | 1.19 (1.03–1.37) | 1.19 (1.03–1.37) | 0.02 | |
| Del/Del | 146 (16) | 253 (15) | 1.13 (0.93–1.37) | 1.14 (0.94–1.38) | 0.18 | |
| Ins/Del+Del/Del | 595 (65) | 1040 (61) | 1.17 (1.02–1.34) | 1.17 (1.03–1.34) | 0.02 | |
a Crude—adjusted for age and sex.
b In addition, adjusted for smoking status, alcohol intake, HRT status (women only), BMI, use of NSAID, intake of red and processed meat, and dietary fibre.
c P-value for the adjusted estimates.