Table 3. IRR for CRC for tertiles of intake of dietary factors for the studied polymorphisms.
| 1.tertile | 2.tertile | 3.tertile | 1.tertile | 2.tertile | 3.tertile | P-value b | 1.tertile | 2.tertile | 3.tertile | 1.tertile | 2.tertile | 3.tertile | P-value b | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nc | Ns | Nc | Ns | Nc | Ns | IRR (95%CI) a | IRR (95%CI) a | IRR (95%CI) a | Nc | Ns | Nc | Ns | Nc | Ns | IRR (95%CI) a | IRR (95%CI) a | IRR (95%CI) a | |||
| TLR4/rs4986790 | Red and processed meat | Fish | ||||||||||||||||||
| AA | 273 | 598 | 248 | 457 | 288 | 522 | 1.00 (ref.) | 1.31 (1.11–1.55) | 1.22 (1.04–1.54) | 279 | 534 | 286 | 496 | 274 | 547 | 1.00 (ref.) | 1.02 (0.86–1.20) | 0.92 (0.77–1.10) | ||
| GA+GG | 29 | 49 | 27 | 48 | 20 | 45 | 1.15 (0.77–1.72) | 1.22 (0.85–1.76) | 0.98 (0.62–1.55) | 0.49 | 27 | 48 | 21 | 46 | 28 | 48 | 1.06 (0.70–1.60) | 0.85 (0.55–1.32) | 0.93 (0.63–1.37) | 0.72 |
| Dietary cereal | Dietary fibre | |||||||||||||||||||
| AA | 282 | 445 | 277 | 534 | 280 | 598 | 1.00 (ref.) | 0.88 (0.74–1.05) | 0.94 (0.75–1.17) | 279 | 479 | 277 | 464 | 283 | 634 | 1.00 (ref.) | 0.99 (0.84–1.16) | 0.81 (0.69–0.96) | ||
| GA+GG | 19 | 44 | 30 | 42 | 27 | 56 | 0.74 (0.46–1.19) | 1.01 (0.69–1.47) | 0.96 (0.64–1.46) | 0.33 | 21 | 48 | 29 | 36 | 26 | 58 | 0.78 (0.49–1.22) | 1.29 (0.88–1.90) | 0.72 (0.49–1.07) | 0.19 |
| Fruit | Vegetables | |||||||||||||||||||
| AA | 275 | 487 | 287 | 535 | 277 | 555 | 1.00 (ref.) | 0.96 (0.81–1.14) | 0.95 (0.77–1.16) | 275 | 466 | 278 | 549 | 286 | 562 | 1.00 (ref.) | 1.02 (0.86–1.21) | 1.08 (0.89–1.32) | ||
| GA+GG | 25 | 39 | 22 | 52 | 29 | 51 | 1.04 (0.69–1.56) | 0.81 (0.52–1.27) | 0.97 (0.66–1.44) | 0.75 | 28 | 34 | 26 | 59 | 22 | 49 | 1.17 (0.79–1.72) | 0.91 (0.60–1.38) | 0.95 (0.62–1.47) | 0.55 |
| Alcohol | ||||||||||||||||||||
| AA | 288 | 517 | 277 | 578 | 274 | 482 | 1.00 (ref.) | 0.92 (0.78–1.08) | 1.10 (0.93–1.31) | |||||||||||
| GA+GG | 33 | 42 | 22 | 53 | 21 | 47 | 1.23 (0.86–1.78) | 0.80 (0.52–1.22) | 0.89 (0.57–1.40) | 0.28 | ||||||||||
| TLR4/rs5030728 | Red and processed meat | Fish | ||||||||||||||||||
| GG | 134 | 295 | 134 | 255 | 137 | 276 | 1.00 (ref.) | 1.19 (0.94–1.51) | 1.08 (0.86–1.36) | 127 | 284 | 139 | 262 | 139 | 280 | 1.00 (ref.) | 1.08 (0.86–1.37) | 1.00 (0.78–1.27) | ||
| GA | 133 | 284 | 134 | 210 | 132 | 237 | 1.00 (0.79–1.27) | 1.34 (1.06–1.69) | 1.26 (1.00–1.60) | 137 | 240 | 131 | 227 | 131 | 264 | 1.21 (0.94–1.54) | 1.13 (0.89–1.44) | 1.03 (0.81–1.32) | ||
| AA | 35 | 68 | 37 | 40 | 39 | 54 | 1.06 (0.73–1.55) | 1.70 (1.19–2.43) | 1.54 (1.09–2.17) | 0.73 | 42 | 58 | 37 | 53 | 32 | 51 | 1.39 (0.99–1.96) | 1.32 (0.92–1.90) | 1.23 (0.83–1.81) | 0.90 |
| GG+GA | 267 | 579 | 268 | 465 | 269 | 513 | 1.00 (ref.) | 1.26 (1.06–1.49) | 1.16 (0.98–1.37) | 264 | 524 | 270 | 489 | 270 | 544 | 1.00 (ref.) | 1.01 (0.85–1.20) | 0.93 (0.78–1.11) | ||
| AA | 35 | 68 | 37 | 40 | 39 | 54 | 1.06 (0.74–1.52) | 1.70 (1.21–2.38) | 1.54 (1.11–2.13) | 0.55 | 42 | 58 | 37 | 53 | 32 | 51 | 1.27 (0.92–1.75) | 1.20 (0.85–1.70) | 1.12 (0.77–1.63) | 0.96 |
| Dietary cereal | Dietary fibre | |||||||||||||||||||
| GG | 125 | 233 | 136 | 275 | 144 | 318 | 1.00 (ref.) | 0.97 (0.76–1.24) | 1.00 (0.76–1.31) | 130 | 254 | 131 | 234 | 144 | 338 | 1.00 (ref.) | 1.05 (0.83–1.33) | 0.83 (0.66–1.05) | ||
| GA | 126 | 211 | 145 | 244 | 128 | 276 | 1.10 (0.85–1.41) | 1.07 (0.84–1.37) | 1.07 (0.81–1.42) | 126 | 223 | 142 | 217 | 131 | 291 | 1.10 (0.86–1.40) | 1.14 (0.91–1.44) | 0.89 (0.70–1.14) | ||
| AA | 50 | 45 | 26 | 57 | 35 | 60 | 1.54 (1.12–2.13) | 0.89 (0.58–1.36) | 1.34 (0.90–2.00) | 0.34 | 44 | 50 | 33 | 49 | 34 | 63 | 1.35 (0.96–1.90) | 1.22 (0.84–1.78) | 1.11 (0.76–1.62) | 0.98 |
| GG+GA | 251 | 444 | 281 | 519 | 272 | 594 | 1.00 (ref.) | 0.97 (0.81–1.17) | 0.99 (0.79–1.23) | 256 | 477 | 273 | 451 | 275 | 629 | 1.00 (ref.) | 1.05 (0.89–1.24) | 0.82 (0.69–0.98) | ||
| AA | 50 | 45 | 26 | 57 | 35 | 60 | 1.48 (1.09–1.99) | 0.85 (0.57–1.28) | 1.28 (0.88–1.87) | 0.10 | 44 | 50 | 33 | 49 | 34 | 63 | 1.30 (0.94–1.78) | 1.17 (0.82–1.67) | 1.06 (0.74–1.52) | 0.79 |
| Fruit | Vegetables | |||||||||||||||||||
| GG | 139 | 264 | 135 | 275 | 131 | 287 | 1.00 (ref.) | 0.98 (0.77–1.24) | 0.91 (0.70–1.18) | 132 | 250 | 130 | 289 | 143 | 287 | 1.00 (ref.) | 1.03 (0.80–1.31) | 1.16 (0.90–1.50) | ||
| GA | 126 | 212 | 136 | 260 | 137 | 259 | 1.10 (0.87–1.40) | 0.98 (0.78–1.25) | 1.07 (0.83–1.39) | 136 | 187 | 129 | 269 | 134 | 275 | 1.28 (1.01–1.62) | 1.06 (0.83–1.35) | 1.15 (0.88–1.50) | ||
| AA | 35 | 50 | 38 | 52 | 38 | 60 | 1.26 (0.88–1.82) | 1.24 (0.87–1.76) | 1.21 (0.83–1.75) | 0.92 | 35 | 63 | 45 | 50 | 31 | 49 | 1.02 (0.70–1.47) | 1.75 (1.26–2.44) | 1.44 (0.96–2.15) | 0.05 |
| GG+GA | 265 | 476 | 271 | 353 | 268 | 546 | 1.00 (ref.) | 0.94 (0.79–1.12) | 0.94 (0.77–1.15) | 268 | 437 | 259 | 558 | 277 | 562 | 1.00 (ref.) | 0.93 (0.78–1.11) | 1.03 (0.84–1.26) | ||
| AA | 35 | 50 | 38 | 52 | 38 | 60 | 1.21 (0.85–1.71) | 1.18 (0.85–1.65) | 1.15 (0.81–1.65) | 0.98 | 35 | 63 | 45 | 50 | 31 | 49 | 0.90 (0.64–1.28) | 1.56 (1.15–2.13) | 1.28 (0.88–1.88) | 0.03 |
| Alcohol | ||||||||||||||||||||
| GG | 133 | 267 | 135 | 306 | 137 | 253 | 1.00 (ref.) | 0.98 (0.78–1.25) | 1.23 (0.97–1.57) | |||||||||||
| GA | 150 | 246 | 128 | 261 | 121 | 224 | 1.23 (0.97–1.54) | 1.07 (0.84–1.36) | 1.21 (0.94–1.55) | |||||||||||
| AA | 38 | 46 | 36 | 64 | 37 | 52 | 1.70 (1.19–2.42) | 1.14 (0.79–1.65) | 1.37 (0.95–1.98) | 0.41 | ||||||||||
| GG+GA | 283 | 513 | 263 | 567 | 258 | 477 | 1.00 (ref.) | 0.92 (0.78–1.09) | 1.10 (0.93–1.31) | |||||||||||
| AA | 38 | 46 | 36 | 64 | 37 | 52 | 1.53 (1.10–2.14) | 1.03 (0.73–1.46) | 1.24 (0.88–1.75) | 0.33 | ||||||||||
| NFKB1/rs28362491 | Red and processed meat | Fish | ||||||||||||||||||
| I/I | 112 | 238 | 102 | 225 | 106 | 216 | 1.00 (ref.) | 1.01 (0.78–1.31) | 1.06 (0.82–1.37) | 99 | 228 | 116 | 214 | 105 | 237 | 1.00 (ref.) | 1.09 (0.84–1.41) | 0.95 (0.72–1.26) | ||
| I/D+D/D | 190 | 409 | 203 | 280 | 202 | 351 | 0.98 (0.78–1.23) | 1.46 (1.17–1.83) | 1.24 (0.99–1.56) | 0.06 | 207 | 354 | 191 | 328 | 197 | 358 | 1.25 (0.98–1.58) | 1.20 (0.94–1.53) | 1.13 (0.88–1.44) | 0.76 |
| Dietary cereal | Dietary fibre | |||||||||||||||||||
| I/I | 105 | 187 | 101 | 212 | 114 | 280 | 1.00 (ref.) | 0.87 (0.66–1.15) | 0.91 (0.68–1.22) | 104 | 202 | 112 | 201 | 104 | 276 | 1.00 (ref.) | 1.05 (0.81–1.36) | 0.75 (0.58–0.99) | ||
| I/D+D/D | 196 | 302 | 206 | 364 | 193 | 374 | 1.10 (0.87–1.39) | 1.04 (0.81–1.32) | 1.13 (0.85–1.50) | 0.76 | 196 | 325 | 194 | 299 | 205 | 416 | 1.14 (0.90–1.44) | 1.16 (0.92–1.46) | 0.97 (0.77–1.23) | 0.66 |
| Fruit | Vegetables | |||||||||||||||||||
| I/I | 113 | 218 | 107 | 216 | 100 | 245 | 1.00 (ref.) | 0.96 (0.74–1.25) | 0.88 (0.66–1.17) | 105 | 199 | 114 | 240 | 101 | 240 | 1.00 (ref.) | 1.16 (0.89–1.50) | 1.11 (0.83–1.49) | ||
| I/D+D/D | 187 | 308 | 202 | 371 | 206 | 361 | 1.15 (0.91–1.45) | 1.07 (0.85–1.35) | 1.12 (0.87–1.45) | 0.70 | 198 | 301 | 190 | 368 | 207 | 371 | 1.31 (1.04–1.65) | 1.19 (0.94–1.52) | 1.33 (1.03–1.71) | 0.37 |
| Alcohol | ||||||||||||||||||||
| I/I | 104 | 230 | 111 | 254 | 105 | 195 | 1.00 (ref.) | 1.08 (0.83–1.40) | 1.32 (1.01–1.73) | |||||||||||
| I/D+D/D | 217 | 329 | 188 | 377 | 190 | 334 | 1.45 (1.15–1.83) | 1.16 (0.92–1.48) | 1.36 (1.08–1.73) | 0.09 | ||||||||||
a Analysis adjusted for smoking status, alcohol intake, HRT status (women only), BMI, use of NSAID, intake of red and processed meat, and dietary fibre.
b P-value for interaction between polymorphisms and dietary factors for the adjusted estimates
Women: Tertiles of red and processed meat (<74.7773 g, 74.7773 g < and < 102.086 g, >102.086 g), fish (<27.2196 g, 27.2196 g < and < 43.6676 g, > 43.6676 g), dietary fibre (<16.9701 g, 16.9701 g < and < 22.0983 g, > 22.0983 g), cereals (<135.539 g, 135.539 g < and < 190.481 g, > 190.481 g), fruit (<141.858 g, 141.858 g < and < 266.488 g, > 266.488 g), vegetables (<121.870 g, 121.870 g < and < 213.721 g, > 213.721 g), laktose (<7.54871 g, 7.54871 g < and < 17.1355 g, > 17.1355 g), dairy products (<218.144 g, 218.144 g < and < 454.235 g, > 454.235 g), alcohol (<4.31931 g, 4.31931 g < and < 12.9957 g, > 12.9957 g).
Men: Tertiles of red and processed meat (<116.935 g, 116.935 g < and < 159.387 g, >159.387 g), fish (<33.3477 g, 33.3477 g < and < 52.7767 g, > 52.7767 g), dietary fibre (<17.5748 g, 17.5748 g < and < 22.4931 g, > 22.4931 g), cereals (<166.378 g, 166.378 g < and < 233.859 g, > 233.859 g), fruit (<90.9913 g, 90.9913 g < and < 193.509 g, > 193.509 g), vegetables (<105.532 g, 105.532 g < and < 186.459 g, > 186.459 g), laktose (<7.93777 g, 7.93777 g < and < 17.2082 g, > 17.2082 g), dairy products (<217.360 g, 217.360 g < and < 461.449 g, > 461.449 g), alcohol (<14.4960 g, 14.4960 g < and < 37.1134 g, > 37.1134 g).