TABLE 3.
Multivariate logistic regression model of clinical and pathologic factors associated with close margins in patients with ductal carcinoma-in situ treated with mastectomy (n = 810)
| Variables | Odds ratio | 95 % CI | p value |
|---|---|---|---|
| Age | |||
| ≤50 years | 1.00 (reference) | ||
| >50 years | 0.68 | 0.33–1.41 | 0.297 |
| Menopausal status | |||
| Premenopausal | 1.00 (reference) | ||
| Postmenopausal | 0.58 | 0.29–1.19 | 0.137 |
| Largest recorded mammographic dimension | |||
| <1.5 cm | 1.00 (reference) | ||
| ≥1.5 cm | 2.87 | 0.81–10.08 | 0.101 |
| Largest recorded pathologic lesion size | |||
| <1.5 cm | 1.00 (reference) | ||
| ≥1.5 cm | 5.11 | 1.94–13.4 | 0.001 |
| Skin-sparing mastectomy | |||
| Yes | 1.10 | 0.56–2.14 | 0.787 |
| No | 1.00 (reference) | ||
| Immediate breast reconstruction | |||
| Yes | 1.00 (reference) | ||
| No | 0.54 | 0.25–1.17 | 0.120 |
| Multicentric | |||
| Yes | 5.44 | 1.23–24.04 | 0.026 |
| No | 1.00 (reference) | ||
| Multifocal | |||
| Yes | 1.00 (reference) | ||
| No | 3.04 | 0.67–13.9 | 0.151 |
| Comedo | |||
| Yes | 1.00 (reference) | ||
| No | 1.15 | 0.66–2.00 | 0.626 |
| Necrosis | |||
| Yes | 2.51 | 1.36–4.63 | 0.003 |
| No | 1.00 (reference) | ||
| Estrogen receptor status | |||
| Positive | 1.00 (reference) | ||
| Negative | 0.53 | 0.26–1.10 | 0.088 |