TABLE 5.
Predictors of locoregional recurrence (LRR) in patients with ductal carcinoma-in situ treated with mastectomy (n = 810)
| Characteristics | Patients with LRR, n (%) | Patients without LRR, n (%) | p value |
|---|---|---|---|
| All patients | 8 (1.0) | 802 (99.0) | |
| Race | |||
| White | 7 (87.5) | 593 (74.0) | |
| African American | 1 (12.5) | 84 (10.5) | |
| Hispanic | 0 (0) | 66 (8.2) | |
| Asian/Pacific Islander | 0 (0) | 46 (5.7) | |
| Other | 0 (0) | 13 (1.6) | 0.831 |
| Age, years, median (range) | 53 (20–88) | 47.5 (41–62) | 0.363 |
| Menopausal statusa | |||
| Premenopausal | 5 (62.5) | 274 (34.2) | |
| Postmenopausal | 3 (37.5) | 526 (65.8) | 0.096 |
| Bilateral breast cancer at diagnosis | |||
| Yes | 1 (12.5) | 99 (12.5) | |
| No | 7 (87.5) | 703 (87.6) | 0.997 |
| Initial presentationb | |||
| Clinical | 1 (12.5) | 187 (23.5) | |
| Radiological | 7 (87.5) | 611 (76.5) | 0.464 |
| Largest recorded mammographic dimension, cm, median (range)c | 2.5 (0.7–14) | 3.5 (0.3–20) | 0.816 |
| Skin-sparing mastectomy | |||
| Yes | 7 (87.5) | 462 (57.5) | |
| No | 1 (12.5) | 340 (42.5) | 0.088 |
| Immediate breast reconstruction | |||
| Yes | 7 (87.5) | 527 (65.8) | |
| No | 1 (12.5) | 275 (34.3) | 0.196 |
| Contralateral prophylactic mastectomy | |||
| Yes | 1 (12.5) | 132 (16.4) | |
| No | 7 (87.5) | 670 (83.6) | 0.765 |
| Largest recorded pathologic lesion size, cm, median (range)d | 1.2 (0.5–8.0) | 2.2 (0.02–19) | 0.659 |
| Nuclear gradee | |||
| I or II | 2 (25.0) | 349 (44.1) | |
| III | 6 (75.0) | 442 (55.9) | 0.278 |
| Margin status | |||
| ≤1 mm | 3 (37.5) | 56 (7.0) | |
| 1.1–2.9 mm | 1 (12.5) | 34 (4.2) | |
| ≥3 mm | 4 (50.0) | 712 (88.8) | 0.002 |
| Multicentricf | |||
| Yes | 5 (100.0) | 242 (38.4) | |
| No | 0 (0) | 389 (61.7) | 0.005 |
| Multifocalg | |||
| Yes | 5 (100.0) | 233 (38.2) | |
| No | 0 (0) | 377 (61.8) | 0.005 |
| Comedoh | |||
| Yes | 2 (25.0) | 250 (32.6) | |
| No | 6 (75.0) | 517 (67.4) | 0.648 |
| Necrosis | |||
| Yes | 6 (75.0) | 378 (47.1) | |
| No | 2 (25.0) | 424 (52.9) | 0.115 |
a
Two patients were perimenopausal
b
Not available for four patients
c
Not available for 423 patients
d
Not available for 181 patients
e
Not available for 11 patients
f
Not available for 174 patients
g
Not available for 195 patients
h
Not available for 35 patients