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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Trends Genet. 2014 Aug 14;30(10):464–474. doi: 10.1016/j.tig.2014.07.005

Figure 3. Regulation of TET expression by proto-oncogenic microRNAs and transcription factors in breast cancer.

Figure 3

Over-expression of oncogenic miR-22 or HMGA2 suppresses TET gene expression. The resulting decrease in TET protein level causes hypermethylation at promoters of genes encoding proteins (TET, the metalloproteinases TIMP, the homeobox transcription factors HOXA7 and HOXA9) or microRNAs (miR-200s) that are involved in suppressing tumor growth and metastasis. miR-200s control expression of several genes including those encoding cadherin (Cdh), the epithelial cell adhesion molecule EpCAM, the transcription factors ZEB1/2, Snail and Slug, and the polycomb group protein Bmi1.