Figure 3.

AnkyrinG and Neurofascin186 distribution remains unchanged with hypoperfusion. A, Axonal AnkyrinG remains within the node of Ranvier in response to hypoperfusion. B, The spatial distribution of Neurofascin186, which connects nodal proteins to the extracellular matrix, does not change. Scale bar, 1 μm. C, There is no significant increase in the length of the AnkyrinG or Neurofascin186 domains after 3 d or 1 month of hypoperfusion in the corpus callosum. Forty nodes per animal were analyzed and these 160–400 nodes are plotted as cumulative frequency (two-sample Kolmogorov–Smirnov test).