Table 4.

Results of Linear Mixed Models for Infant Neurobehavior Subscales (NNNS)

	Main Effects						Interaction			Covariate
	Medication			Assessment Day			Medication X Day			Morphine Dose
	df(den)	F	p	df(den)	F	p	df(den)	F	p	df(den)	F	p
Attention	153.21	0.04	0.839	51.33	10.90	<.001	50.24	0.50	0.77	108.88	8.83	0.004
Quality of Movement	179.73	0.55	0.461	54.49	19.78	<.001	54.11	1.17	0.34	146.25	10.02	0.002
Self-Regulation	175.07	4.21	0.042	58.82	8.88	<.001	57.96	1.06	0.39	149.37	5.24	0.023
Non-Optimal Reflexes	181.40	1.72	0.191	60.66	0.92	0.476	59.51	0.81	0.55	144.56	0.14	0.711
Asymmetrical Reflexes	166.58	3.08	0.081	51.13	0.71	0.618	50.60	0.56	0.73	136.15	0.34	0.558
Stress-Abst Signs TOT.	168.46	12.94	<.001	53.30	0.21	0.957	52.13	0.68	0.64	157.14	4.25	0.041
Handling	172.30	11.40	0.001	54.56	4.13	0.003	53.18	0.62	0.68	162.50	0.05	0.827
Arousal	177.05	7.82	0.006	57.16	5.19	0.001	55.81	1.84	0.12	166.67	0.01	0.936
Excitability	184.57	12.70	<.001	64.10	8.41	<.001	63.55	1.71	0.15	156.60	0.97	0.327
Depression	164.00	1.80	0.182	74.95	4.67	0.001	75.22	0.32	0.90	148.24	13.53	<.001
Hypertonia	114.99	7.50	0.007	53.99	3.75	0.006	52.22	2.31	0.06	92.16	0.03	0.873
Hypotonia	147.99	0.16	0.689	55.52	0.50	0.777	55.52	1.09	0.38	131.64	0.22	0.639

Note: df(num) is 1 for medication condition and covariate, and 5 for Assessment Day and Medication Condition X Assessment Day interaction