Table 1. Basic characteristics of acute hepatitis B patients by region of reporting, notified between 2009–2013 in the Netherlands.
| Brabant/Zeeland | Limburg | Noord | Noord-Holland | Oost | Utrecht | Zuid-Holland Noord | Zuid-Holland Zuid | Total | ||
|---|---|---|---|---|---|---|---|---|---|---|
| n = 173 | n = 52 | n = 135 | n = 145 | n = 129 | n = 45 | n = 63 | n = 139 | n = 881 | ||
| N(%) | N(%) | N(%) | N(%) | N(%) | N(%) | N(%) | N(%) | P-value | N(%) | |
| Incidence per 100,000* | ||||||||||
| Total | 1.22 | 0.93 | 1.57 | 0.94 | 0.82 | 0.73 | 1.23 | 1.11 | 0.000 | 1.06 |
| Men | 1.99 | 1.55 | 2.65 | 1.25 | 1.32 | 1.13 | 1.93 | 1.74 | 0.000 | 1.66 |
| Women | 0.45 | 0.32 | 0.51 | 0.64 | 0.33 | 0.35 | 0.54 | 0.50 | 0.128 | 0.47 |
| Sex | ||||||||||
| Men | 141 (81.5) | 43 (82.7) | 113 (83.7) | 95 (65.5) | 103 (79.8) | 34 (75.6) | 49 (77.8) | 107 (77.0) | 0.012 | 685 (77.8) |
| Women | 32 (18.5) | 9 (17.3) | 22 (16.3) | 50 (34.5) | 26 (20.2) | 11 (24.4) | 14 (22.2) | 32 (23.0) | 196 (22.3) | |
| Age | ||||||||||
| Median | 42.5 | 45.0 | 45.0 | 38.0 | 47.0 | 32.0 | 38.0 | 45.0 | <0.0001 | 43.0 |
| (IQR) | (33.0–51.0) | (34.5–57.5) | (30.0–54.0) | (28.0–47.0) | (31.0–60.0) | (25.0–45.0) | (27.0–52.0) | (34.0–57.0) | (30.0–53.5) | |
| Ethnicity | ||||||||||
| Dutch | 139 (80.4) | 47 (90.4) | 113 (83.7) | 103 (71.0) | 119 (92.3) | 35 (77.8) | 41 (65.1) | 109 (78.4) | <0.0001 | 706 (80.1) |
| Non-Dutch | 34 (19.6) | 5 (9.6) | 22 (16.3) | 42 (29.0) | 10 (7.7) | 10 (22.2) | 22 (34.9) | 30 (21.6) | 175 (19.9) | |
| Transmission route | ||||||||||
| Heterosexual men | 32 (18.5) | 8 (15.4) | 19 (14.1) | 35 (24.1) | 22 (17.1) | 13 (28.9) | 19 (30.2) | 33 (23.7) | 0.004 | 181 (20.5) |
| MSM | 49 (28.3) | 18 (34.6) | 42 (31.1) | 35 (24.1) | 32 (24.8) | 9 (20.0) | 12 (19.1) | 42 (30.2) | 239 (27.1) | |
| Women—sex. contact | 24 (13.9) | 7 (13.5) | 16 (11.9) | 38 (26.2) | 19 (14.7) | 9 (20.0) | 10 (15.9) | 23 (16.6) | 146 (16.6) | |
| Other | 16 (9.3) | 4 (7.7) | 5 (3.7) | 7 (4.8) | 13 (10.1) | 3 (6.7) | 9 (14.3) | 14 (10.1) | 71 (8.1) | |
| Unknown-men | 48 (27.8) | 14 (26.9) | 47 (34.8) | 23 (15.9) | 39 (30.2) | 10 (22.2) | 9 (14.3) | 22 (15.8) | 212 (24.1) | |
| Unknown-women | 4 (2.3) | 1 (1.9) | 6 (4.4) | 7 (4.8) | 4 (3.1) | 1 (2.2) | 4 (6.4) | 5 (3.6) | 32 (3.6) | |
| Number sequenced | ||||||||||
| S-gene | 79 (45.7) | 41 (78.8) | 91 (67.4) | 53 (36.6) | 74 (57.4) | 21 (46.7) | 25 (39.7) | 47 (33.8) | <0.0001 | 431 (48.9) |
| Genotype based on S-gene | ||||||||||
| A | 62 (78.5) | 29 (70.7) | 80 (87.9) | 27 (50.9) | 56 (75.7) | 11 (52.4) | 12 (48.0) | 31 (66.0) | 0.000 | 308 (71.5) |
| B | 2 (2.5) | 0 (0.0) | 1 (1.1) | 3 (5.7) | 2 (2.7) | 1 (4.8) | 0 (0.0) | 2 (4.3) | 11 (2.6) | |
| C | 4 (5.1) | 3 (7.3) | 3 (3.3) | 2 (3.8) | 4 (5.4) | 3 (14.3) | 3 (12.0) | 5 (10.6) | 27 (6.3) | |
| D | 5 (6.3) | 4 (9.8) | 4 (4.4) | 18 (34.0) | 8 (10.8) | 6 (28.6) | 7 (28.0) | 6 (12.8) | 58 (13.5) | |
| E | 5 (6.3) | 2 (4.9) | 2 (2.2) | 2 (3.8) | 4 (5.4) | 0 (0.0) | 2 (8.0) | 2 (4.3) | 19 (4.4) | |
| F | 1 (1.3) | 3 (7.3) | 1 (1.1) | 1 (1.9) | 0 (0.0) | 0 (0.0) | 1 (4.0) | 1 (2.1) | 8 (1.9) |
*The incidence was calculated as the average over the yearly incidences in 2009–2013