Table 1. Scoring criteria of Immunohistochemistry (IHC) assay with specific antibodies used in this study.

Staining positive cells		Staining intensity		Final score product
Percent (%)	Score 1	Intensity	Score 2	Score 1 x Score 2	Score 3
≤5%	0	absent	0	0–1	0 (-)
6%-25%	1	weak	1	2–4	1+ (+)
26%-50%	2	moderate	2	5–8	2+ (++)
51%-75%	3	strong	3	9–12	3+ (+++)
76%-100%	4

Note: Scoring results are based on screening 12 consecutive microscopic fields. Percent positive cells (score 1) multiply staining intensity (score 2) equals to final product score (score 3). Either 0 or (-) depicts negative staining. For example, an individual slide had <5% of staining cells (= 0) with a staining intensity of 1 (= weak) which would generate a final product score of 0 X 1 = 0; another slide had 80% of staining cells (= 4) with a staining intensity of 3 (= strong) which would give a final product score of 4 X 3 = 12 (3+).