Table 3. Subgroup analyses of pooled hazard ratios for overall survival with elevated miR-21 expression.
| Subgroup analysis | Data sets (number) | Number of patients | Model | HR(95% CI) | P value | Heterogeneity (I2, P-value) |
|---|---|---|---|---|---|---|
| All | 9 | 1,296 | Random | 2.57(1.37–4.81) | 0.003 | 69.4%, 0.001 |
| Ethnicity | ||||||
| Asian | 3 | 513 | Fixed | 5.07(2.89–8.92) | <0.001 | 45%, 0.162 |
| Caucasian | 6 | 783 | Fixed | 1.44(0.99–2.10) | 0.058 | 46.6%, 0.096 |
| Cut-off | ||||||
| Mean | 2 | 222 | Random | 7.06(2.13–23.45) | 0.001 | 63.1%, 0.1 |
| Median | 6 | 783 | Fixed | 1.44(0.99–2.10) | 0.058 | 46.6%, 0.096 |
| Type | ||||||
| Mixed | 6 | 994 | Random | 2.41(1.09–5.32) | 0.029 | 77.8%, <0.001 |
| Her2+ | 2 | 253 | Fixed | 4.227(1.81–9.90) | 0.001 | 0%, 0.618 |
| Triple-negative | 1 | 49 | 0.85(0.09–8.29) | 0.337 |