Table 2. Multivariate associations of the three tagSNPs in SIRT1 gene with the risk of MI.
| Type | Controls (n = 654) No. (%) | Cases (n = 287) No. (%) | OR (95% CI) a | P a | P c |
|---|---|---|---|---|---|
| rs7069102 | |||||
| C | 1128 (86.2) | 469 (81.7) | 1.00 | - | |
| G | 180 (13.8) | 105 (18.3) | 1.57 (1.15–2.16) | 0.005 | 0.015 b |
| CC | 486 (74.3) | 192 (66.9) | 1.00 | - | |
| CG+GG | 168 (25.7) | 95 (33.1) | 1.64 (1.14–2.35) | 0.007 | 0.021 |
| rs3818292 | |||||
| A | 942 (72.0) | 418 (72.8) | 1.00 | - | |
| G | 366 (28.0) | 156 (27.2) | 0.89 (0.69–1.16) | 0.393 | NS |
| GG | 56 (8.6) | 27 (9.4) | 1.00 | - | |
| AG+AA | 598 (91.4) | 260 (90.6) | 0.98 (0.54–1.77) | 0.932 | NS |
| rs4746720 | |||||
| C | 564 (43.1) | 242 (42.2) | 1.00 | - | |
| T | 744 (56.9) | 332 (57.8) | 1.11 (0.88–1.42) | 0.383 | NS |
| CC | 119 (18.2) | 46 (16.0) | 1.00 | - | |
| CT+TT | 535 (81.8) | 241 (84.0) | 1.20 (0.77–1.85) | 0.419 | NS |
P c, Bonferroni corrected P; NS, not significant.
a Adjusted for age, sex, BMI, smoking, drinking, hypertension, diabetes and hyperlipidemia.
b P c values under 0.05 were indicated in bold font.