Table 3. Multivariate associations of the rs7069102 in SIRT1 gene with the risk of MI by further stratification for age.
| Type | Controls No. (%) | Cases No. (%) | OR (95% CI) a | P a | P c |
|---|---|---|---|---|---|
| ≤55 | n = 214 | n = 93 | |||
| C | 381 (89.0) | 152 (81.7) | 1.00 | - | |
| G | 47 (11.0) | 34 (18.3) | 2.21 (1.13–4.31) | 0.020 | 0.040 b |
| CC | 168 (78.5) | 60 (64.5) | 1.00 | - | |
| CG+GG | 46 (21.5) | 33 (35.5) | 2.27 (1.13–4.55) | 0.021 | 0.042 |
| >55 | n = 440 | n = 194 | |||
| C | 747 (84.9) | 317 (81.7) | 1.00 | - | |
| G | 133 (15.1) | 71 (18.3) | 1.32 (0.91–1.90) | 0.141 | NS |
| CC | 318 (72.3) | 132 (68.0) | 1.00 | - | |
| CG+GG | 122 (27.7) | 62 (32.0) | 1.33 (0.87–2.05) | 0.192 | NS |
P c, Bonferroni corrected P; NS, not significant.
a Adjusted for sex, BMI, smoking, drinking, hypertension, diabetes and hyperlipidemia.
b P c values under 0.05 were indicated in bold font.