Table 5. Association between haplotypes of the three tagSNPs in SIRT1 gene with the risk of MI among younger subjects (≤ 55 years old).
Haplotype a | Controls (n = 214) No. (%) | Cases (n = 93) No. (%) | OR (95% CI) | P | P c |
---|---|---|---|---|---|
C A C | 202.00 (47.2) | 78.00 (41.9) | 0.81 (0.57–1.14) | 0.229 | NS |
C A T | 55.00 (12.9) | 29.00 (15.6) | 1.25 (0.77–2.04) | 0.364 | NS |
C G T | 124.00 (29.0) | 45.00 (24.2) | 0.78 (0.53–1.16) | 0.223 | NS |
G A T | 47.00 (11.0) | 34.00 (18.3) | 1.81 (1.12–2.93) | 0.014 | 0.056 |
P c, Bonferroni corrected P; NS, not significant.
a The allelic sequence in the haplotypes is in the following order: rs7069102, rs3818292, rs4746720.