Table 1. Demographic and clinical characteristics of patients with CHD but without any previous history of malignancy.

	Total	Male	Female	p
No. of patients, n (%)	31,961	15,156 (47.4)	16,805 (52.6)
Age at CHD diagnosis, years, n (%)
0–5	17,678 (55.3)	8,635 (57.0)	9,043 (53.8)
6–17	5,676 (17.8)	2,754 (18.2)	2,922 (17.4)
18–44	5,722 (17.9)	2,542 (16.8)	3,180 (18.9)
45–64	2,184 (6.8)	929 (6.1)	1,255 (7.5)
≥ 65	701 (2.2)	296 (2.0)	405 (2.4)
Median age at diagnosis, years (IQR)	3.5 (0.2–19.7)	2.9 (0.2–17.8)	4.1 (0.3–22.0)	<0.001
Median follow-up period, years (IQR)	5.2 (2.7–7.6)	5.3 (2.7–7.6)	5.2 (2.7–7.5)	0.422
Person-years at cancer risk	163,430	77,696	85,734
Co-morbidity, n (%)
Heart failure	4,149 (13.0)	1,929 (12.7)	2,220 (13.2)	0.200
Chronic pulmonary disease	3,864 (12.1)	1,774 (11.7)	2,090 (12.4)	0.045
Scoliosis	2,009 (6.3)	1,063 (7.0)	946 (5.6)	<0.001
Cerebrovascular disease	1,446 (4.5)	745 (4.9)	701 (4.2)	0.001
Chronic liver disease	1,182 (3.7)	570 (3.8)	612 (3.6)	0.573
Diabetes mellitus	805 (2.5)	329 (2.2)	476 (2.8)	<0.001
Chromosomal anomaly	734 (2.3)	346 (2.3)	388 (2.3)	0.877
Epilepsy	598 (1.9)	321 (2.1)	277 (1.6)	0.002
Peripheral vascular disease	411 (1.3)	237 (1.6)	174 (1.0)	<0.001
Chronic kidney disease	409 (1.3)	189 (1.2)	220 (1.3)	0.622
Congenital respiratory anomaly	353 (1.1)	193 (1.3)	160 (1.0)	0.006
Mental retardation	304 (1.0)	159 (1.0)	145 (0.9)	0.087
Rheumatologic disease	223 (0.7)	63 (0.4)	160 (1.0)	<0.001
Cerebral palsy	224 (0.7)	111 (0.7)	113 (0.7)	0.521
Catheterization	15,613 (48.9)	7,242 (47.8)	8,371 (49.8)	<0.001
CT scan	6,051 (18.9)	3,113 (20.5)	2,938 (17.5)	<0.001

Abbreviations: CHD, Congenital heart disease; CT, computed tomography; IQR, inter-quartile range

p value, statistically significant difference between male and female patients with CHD