Figure 4.

Brain atrophy of 3-month R6/2 mice was alleviated under oral B401 treatment.

Notes: (A) Magnetic resonance images corresponding to the brain at different cross- and longitudinal-section in 3-month R6/2 mice with oral B401 treatment (a–d) is less than those with sham treatment (e–h). (B) The volume (a) and weight (b) of the cerebrum, midbrain, and cerebellum in 3-month R6/2 mice with oral B401 treatment (HD mice oral B401, n=6) are significantly greater than those with sham treatment (HD mice sham, n=6). Values are mean ± SEM (*P<0.05, one-way ANOVA followed by a Student–Newman–Keuls multiple comparisons posttest).

Abbreviations: HD, Huntington’s disease; SEM, standard error of the mean; ANOVA, analysis of variance.