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. 2015 Feb 16;9:887–900. doi: 10.2147/DDDT.S78015

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic diagram illustrates that R6/2 HD mice under B401 treatment may improve neuroprotection via enhancing brain BDNF and VEGF gene expressions, and alleviate neurodegeneration via reducing mutant huntingtin (mHTT) aggregation, TNF-α gene expression (a marker of inflammation), and glutamate-induced excitotoxicity in the brain.

Abbreviations: BDNF, brain-derived neurotrophic factor; VEGF, vascular endothelial growth factor; TNF-α, tumor necrosis factor-alpha; HD, Huntington’s disease.