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. 2015 Feb 23;10(2):e0118806. doi: 10.1371/journal.pone.0118806

Fig 4. Pathogenesis of the M138L deficient strains in NZW rabbits.

Fig 4

NZW rabbits were inoculated with 100 PFUs of Myxoma virus WT, M138L Del, M138L STOP or M138L Rev strains in the left flank. A. Daily clinical scores that evaluated the physical condition and clinical signs of primary and systemic infection were obtained. Clinical scores in the WT and M138L Rev groups were recorded until animals reached euthanasia criteria (significant respiratory distress, or no food or water intake for 48 h, or a clinical score of 15 for two consecutive days). B. The results were analyzed for survival rates among the groups. The daily percentage of survival in each group was plotted to generate the survival curve. The data were analyzed by log-rank (Mantel-Cox) test, * p<0.05. C. Size of the primary lesions of NZW rabbits infected with the different Myxoma virus strains. Daily measurements of the lesion area were recorded. The data presented are the average +/- SEMs. D. Evolution of the temperatures of the infected rabbits. The data presented are the average +/- SEMs. E. Pictures of primary myxomas at days 4 and 7 p.i. These pictures are representative of observations done at least on 4 rabbits. The scale bar on the first image refers to all the images.