Table 2. Major histological differences between European rabbits infected by the WT and M138L Rev strains of the Myxoma virus and the M138L knockout strains.

Day	WT or M138L Rev MYXV strains	M138L Del or STOP MYXV strains
4	Primary sites	Primary sites
	Epidermal hyperplasia, dermal edema and congestion. Mild focal inflammatory reaction with sparse number of infiltrating neutrophils visible in the dermal tissues below areas of viral replication.	Epidermal hyperplasia, dermal edema and congestion. Intense neutrophil infiltration throughout the dermis.
	Lymph nodes	Lymph nodes
	Lots of neutrophils. High number of apoptotic bodies.	Mainly lymphocytes. Presence of germinal centers.
9	Primary sites	Primary sites
	Epidermal hyperplasia with ballooning degeneration and micro-vesicle formation. Acute coagulation necrosis of epidermis and dermis, dermal edema and congestion. Intense inflammatory reaction in deep dermis with neutrophils dominating (90%).	Epidermal hyperplasia. Coagulation necrosis of epidermis and dermis, dermal edema and congestion. Intense, widespread mononuclear cell infiltrate throughout the dermis. Neutrophils almost absent.
	Lymph nodes	Lymph nodes
	Architecture disorganization. Edema and neutrophils. Nearly no lymphocytes	Intense congestion. Lots of germinal centers. No neutrophils.