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. 2015 Jan 16;4(3):164–174. doi: 10.1016/j.molmet.2014.12.010

Figure 6.

Figure 6

Osteoblastic specific Y1 receptor deletion mediates insulin production independently of osteocalcin. Quantitative real-time PCR expression of ESP, Foxo1, OPG and osteocalcin (OSC) genes in femoral RNA from Y1F3.6Cre and control mice (A). Serum osteocalcin levels in Y1F3.6Cre and control mice (B). Quantitative real-time PCR expression of Ins1 (C) and Ins2 (D) genes in MIN6 cells cultured with the addition of supernatant from wildtype or Y1F3.6Cre bone marrow stromal cells cultured under control or osteogenic (OB) conditions. Glucose-stimulated insulin secretion is unaltered in islets isolated from Y1F3.6Cre mice compared to wildtype (E). Data are means ± SEM of 5–6 mice per group (A), 5-9 mice per group (B), 3 mice per group (C–D), 7 mice per group across 2 experiments (E). * = p < 0.05 versus control or as indicated.