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. 2015 Mar;21(3):307–319. doi: 10.1261/rna.046862.114

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© 2015 Nyayanit and Gadgil; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 2. — Schematic representation for the model. mRNA (m₁) associates and dissociates with miRNAs (μ₁ and μ₂) forming complexes c₁₁ and c₁₂. These complexes formed can be stoichiometrically degraded (rate constants d₁₁^c, d₁₂^c), selectively degraded (nonstoichiometric degradation, rate constants k₁₁^retm/μ and k₁₂^retm/μ), or can be associated with second miRNA to form combicomplex (c₁₁₂). The combicomplex formed can be stoichiometrically degraded. mRNA, complexes, and combicomplexes translate to form protein. The rate parameters are depicted in italics and species in bold. Unfilled arrows depict catalytic formation of protein from complexes and mRNA, dashed arrows represent nonstoichiometric degradation of one species from the complex returning the other species. (Ø) Sink/source.